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In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

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This precipitate is not suitable for a pigment until it is filtered, dried, crushed, heated to a high temperature, and quenched in cold water. The second heating in a muffle furnace at 725 C produces crystals of the right optical size.

In the paper industry, art painting supplies level, use as a white opaque pigment for a variety of printing paper filler, white pigment for pencils, watercolors, art painting.

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The RGB LED panel was made ad hoc, and configured for solar simulation white light (including the absorption spectra of the nanoparticles: 390–410). No heat was detected at the working distance. The retina of the albino male Wistar rats were not affected under these conditions, because the intensity and time of the applied irradiation was lower than the regular fluorescent lamp bulb in the room (216.65 W/m2) [34].

Blanc de Comines, 27 per cent zinc sulphide, 70.5 per cent barium sulphate, 2.5 per cent zinc carbonate.

Of the products that include the additive in their labels, Thea Bourianne, senior manager at data consultant Label Insights, told Food Navigator USA in May 2021 that more than 11,000 products in the company's database of U.S. food and beverage products listed titanium dioxide as an ingredient. Non-chocolate candy led those numbers at 32%. Cupcakes and snack cakes made up 14%, followed by cookies at 8%, coated pretzels and trail mix at 7%, baking decorations at 6%, gum and mints at 4% and ice cream at 2%.

Exposure to titanium dioxide in utero and in breastfeeding children

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On the other hand, titanium dioxide is a synthetic mineral that is produced through a chemical reaction involving the mineral ilmenite or rutile. It is used in industries such as cosmetics, paint, and sunscreen as a whitening agent and pigment. The manufacturing process of titanium dioxide involves extracting the mineral from ores, purifying it through chemical processes, and then grinding it into a fine powder.

Lithopone is an inorganic white pigment, obtained from co-precipitation of Zinc sulfide (ZnS) and Barium sulfate (BaSO4). Titanium Dioxide (TiO2) has replaced Lithopone as a white pigment in majority applications as TiO2 is more durable. However, it is much cheaper than TiO2 and has advantages such as low binder requirement and good dispensability. As a white pigment, it can improve the substrate's weather resistance, and improve the fungicidal properties of paint formulations. Some of the major applications of Lithopone include manufacturing of paint pigments, plastic & rubber products, paper, printing inks, cosmetics, and leather & linoleum products. It is commercially available under names such as pigment white 5, Barium zinc sulfate sulfide, Becton White, C.I. 77115, Charlton White, Enamel White, and Zincolith. On the basis of content of ZnS, Lithopone is available at 28%-30% Lithopone and 60% Lithopone.

A 2012 study published in the journal Environmental Science & Technology noted that children are especially exposed to titanium dioxide because of the food that contains the food additive and is particularly marketed to children, including candy and cakes.